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Biocompatible Material Development Division

Conduct research mainly on biocompatible materials in cooperation with the Development Strategy Division

In collaboration with the Development Strategy Division, we will conduct needs provision, development and assessment of biocompatible materials required for implantable medical devices (e.g., magnesium alloys and zinc alloys for surgical clips, staples, stents, and radiation therapy markers).

Research topic

Research on biodegradable implant

Metallic materials are widely used in a medical setting as devices for clamping and sustaining body tissues which require treatment by accident or disease, because they maintain high strength for a long time. For example, titanium alloys have high strength, corrosion resistance and biocompatibility, thus they are applied to devices such as clips for clamping tissues, plates for bone junction and artificial hip joints. On the other hand, after body tissues are treated, artificial devices are not required. Those devices often cause CT artifacts and inflammations, therefore biodegradable devices, which are degraded in vivo with time and eliminated from the body, have received a lot of attention. Then, in this research project we focus on magnesium and zinc which are essential elements and biodegradable, and conduct a study for applying those metals to devices for clamping tissues. Specifically, we carry out optimum design of materials and configurations for devices, prototype fabrication of model devices and performance validation by collaborative experiment with medical researchers.


Professor Toshiji Mukai, Assistant Professor Naoko Ikeo

Research on Fatigue strength evaluation for metallic biomaterials

Metallic biomaterials are used in medical devices such as artificial joints and bone plates. Metallic materials subjected to small cyclic loads break after prolonged use (called as fatigue). In structures such as airplanes and railways, the strength against fatigue of materials is evaluated to prevent accidents caused by fatigue. The fatigue strength In vivo is reduced compared to the atmospheric environment due to the influence of chemical and biochemical factors. In order to use metallic biomaterials safely for a long period of time, it is necessary to evaluate the fatigue strength of the materials in the vivo environment. In this study, research on the evaluation of fatigue crack growth characteristics and the elucidation of a mechanism of the crack initiation for metallic biomaterials are conducted using infrared thermography and synchrotron radiation CT imaging.


Associate Professor Daiki Shiozawa

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